Anastrozole is an aromatase inhibitor (AI) sometimes used in conjunction with testosterone replacement therapy (TRT). Aromatase is an enzyme that converts testosterone into estrogen. During TRT, elevated testosterone levels can lead to increased estrogen conversion, potentially causing side effects such as gynecomastia (breast tissue growth), water retention, and mood swings. AIs like anastrozole work by blocking the aromatase enzyme, thereby reducing estrogen levels.
Maintaining appropriate estrogen levels within a healthy range is crucial for overall well-being during TRT. Excessive estrogen can have negative impacts, while insufficient estrogen can also lead to health concerns such as bone density loss and decreased libido. Finding the optimal AI dosage is an individualized process, requiring careful monitoring of estrogen levels through blood tests. Historically, AI use has been somewhat controversial due to the potential for overly suppressing estrogen. However, with proper medical supervision and regular blood work, potential risks can be mitigated.
